张慧莉,女,出生于1978年11月,石河子大学生命科学学院副教授。2012获浙江大学生物化工专业博士学位。2015年获得硕士研究生导师资格。
研究兴趣
高附加值生物化学品及微生物药物生产菌的菌种选育、发酵工艺研究和代谢工程,当前主要从事聚谷氨酸、普鲁兰多糖、维生素K2及抗生素的发酵菌种筛选、代谢调控、产物的分离纯化等方面的研究。
主持或参加科研项目(课题)
(1)兵团科技计划项目,《微生物法高效生产截短侧耳素、黄霉素及硫酸新霉素的菌种技术研发》,主持,2021-2023,25万元
(2)浙大阳光生物科技有限公司横向课题,硫酸锌霉素高产菌株的选育,2018-2019,10万元,主持,结题
(3)国家自然科学基金委员会,地区基金,21366028,草酸触发枯草芽孢杆菌高效合成γ-聚谷氨酸的代谢机制,2014-01至2017-12,50万元,已结题,主持
(4)国家自然科学基金委员会,面上项目,31272416,基于猪生殖系统研究嵌合RNA的形成新机制及其繁殖调控功能,2013-01至2016-12,80万元,已结题,参加;
(5)国家自然科学基金委员会,青年项目,31060149,新疆特色植物小拟南芥耐盐相关基因的挖掘和功能研究,2011-01至2013-12,25万元,已结题,参加;
承担的主要课程
本科生 《微生物学》、《食用菌资源学》、《发酵工程实验》
研究生《遗传学专论》、《微生物资源》、《合成生物学》
发表的论文/专著/教材
(1) Zhongmin Tang; Huili Zhang; Jie Xiong; Yang Li; Wei Luo ; Enhanced iturin a production in a two-compartment biofilm reactor by Bacillus velezensis ND, Frontiers in Bioengineering and Biotechnology, 2023, 11: 1-9 (通讯作者)
(2) Liu W, Si Z, Zhang H, Wei P, Xu Z. Efficient poly (β-L-malic acid) production from cassava hydrolysate by cell recycle of Aureobasidium pullulans. Appl Microbiol Biotechnol. 2022. 106(8):2855-2868.
(3) Zhongmin Tang; Xiaojie Cao; Huili Zhang ; Production of iturin A by Bacillus velezensis ND and its biological control characteristics, Journal of Basic Microbiology, 2022, 63(2): 179-189 (通讯作者)
(4) Changle Zhao, Yinping Wan, Xiaojie Cao, Huili Zhang*, Xin Bao Comparative genomics and analysis of the mechanism of PQQ overproduction in Methylobacterium. World Journal of Microbiology and Biotechnology 37.6(2021):1-10. (通讯作者)
(5) Changle Zhao; Yinpin Wan; Guixiang Tang,; Qing Jin; Huili Zhang*; Zhinan Xu; Comparison of different fermentation processes for the Vitamin K2 (Menaquinone-7) production by a novel Bacillus velezensis ND strain, Process Biochemistry, 2020, 102(9): 33-41. (通讯作者)
(6) 曹小洁,万银平,赵长乐,张慧莉*.伊枯草菌素A高产菌株的筛选鉴定及发酵工艺研究,中国酿造,2021(通讯作者,)
(7) 赵长乐,张慧莉,张雪,豆宇杰,包鑫.一株新的产吡咯喹啉醌甲基营养菌全基因组测序和比较基因组学分析,微生物学通报,2020,47(12):4182-4195(通讯作者)
(8) 赵长乐,汤贵祥 ,万银平,黄晓梅,张慧莉.产维生素K2贝莱斯芽孢杆菌ND 的诱变育种及突变子快速筛选,复旦学报(自然科学版),2020(12):670-678(通讯作者)
(9) Wei Luo*, Jiagui Hu, Jiapeng Lu, Huili Zhang, Xiaoping Wang, Yuantao Liu, Liqing Dong, Xiaobin Yu .One pot cascade synthesis of L-2-aminobutyric acid employing ω-transaminase from Paracoccus pantotrophus. Molecular Catalysis. 515 (2021) 111890
(10) Wei Luo*, Jinglong Xu, Huiying Chen, Huili Zhang, Peilong Yang and Xiaobin Yu. Synthesis of L-asparagine Catalyzed by a Novel Asparagine Synthase Coupled With an ATP Regeneration System. Frontiers in Bioengineering and Biotechnology, 2021, 9.
(11) Wei Luo, Chao Xue, Yuzheng Zhao, Huili Zhang, et. al.. Identification and Functional Analysis of Photoreceptors in Blakeslea trispora. Appl. Environ. Microbiol.2020(86)8
(12) Wei Luo, Zunyang Gong, Na Li, Yuzheng Zhao, Huili Zhang, Xue Yang. A negative regulator of carotenogenesis in Blakeslea trispora Appl. Environ. Microbiol. 2020(86)6.
(13) Wei Luo, Jing Zhu, Yuzheng Zhao, Huili Zhang, et. al. Cloning and Expression of a Novel Leucine Dehydrogenase: Characterization and L-tert-Leucine Production[J]. Frontiers in Bioengineering and Biotechnology, 2020, 8.
(14) 汤贵祥,陈朋友,包鑫,杨瑞丽,张慧莉*,MK-7 高产菌株的筛选与发酵条件优化[J]. 食品工业科技,2019(24):68-73 (通讯作者)
(15) Huili Zhang*; Jianzhong Zhu; Xiangcheng Zhu; Jin Cai; Anyi Zhang; Yizhi Hong; Jin Huang; Lei Huang; Zhinan Xu*; High-level exogenous glutamic acid-independent production of poly-(γ-glutamic acid) with organic acid addition in a new isolated Bacillus subtilis C10 , Bioresource Technology, 2012, 116: 241-246.
(16) Zhang, Huili*; Cai, Jin; Dong, Jiaqi; Zhang, Danping; Huang, Lei; Xu, Zhinan*; Cen, Peilin; High-level production of poly (beta-L-malic acid) with a new isolated Aureobasidium pullulans strain, Applied Microbiology and Biotechnology, 2011, 92(2): 295-303.
(17) Jin Huang, Yinming Du, Guohua Xu, Huili Zhang, Fan Zhu, Lei Huang, Zhinan Xu. High yield and cost-effective production of poly (γ-glutamic acid) with Bacillus subtilis. Eng. Life Sci. 2011, 11: 1–7.
(18) Zhinan Xu, Huili Zhang, Hao Chen , Jin Huang, Xiao Song, Shufang Wang, Chenjiang Song. Invited book chapter: Microbial Production of Poly-γ-Glutamic Acid. Book title: Bioprocessing Technologies in Integrated Biorefinery for Production of Biofuels, Biochemicals, and Biopolymers from Biomass, John Wiley & Sons, Inc. New Jersey, USA 2013
(19) 工业微生物学实验技术教程,副主编,武汉大学出版社,2019.4
发明专利
徐志南,张慧莉,黄磊,蔡谨. 一种产生聚苹果酸的菌株及利用其发酵生产聚苹果酸的方法.2013.01.02, 中国,ZL201110131566.4 授权
张慧莉;包鑫;冯世红;曹小洁;赵长乐.贝莱斯芽孢杆菌及联产维生素K2和伊枯草菌素A的方法2020.12.31. 中国,CN202011636275.6授权
电子信箱、联系电话
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